ESP Isn’t Going Away — Here’s How to Keep Up Without Burning Out

The 340B ESP platform continues to evolve — and for most covered entities, that means more deadlines, more data submissions, and more pressure on already stretched teams.

At RxTrail, we’ve worked with dozens of hospitals, health centers, and pharmacies who are tired of reacting to ESP. One thing has become clear: the old once-a-month submission rhythm isn’t cutting it anymore.

That’s why we created a free ESP Workflow Toolkit — built around a biweekly model designed to reduce last-minute scrambles, missed claims, and rejected files.

Inside the toolkit, we walk through:

• How to assign roles and responsibilities within your team
• The cadence we recommend to stay ahead of manufacturer updates
• Tips for pulling, validating, and tracking ESP submissions efficiently
• A simple, repeatable system you can adopt today

If you’re still treating ESP like a monthly task, this guide will show you how to transition to a sustainable, audit-friendly process that fits into your team’s existing structure.